Oblique Plane Microscopy (OPM) is a type of light-sheet fluorescence microscopy that uses a single microscope objective to generate the illumination light sheet and detect the resulting fluorescence. The light sheet is tilted with respect to the optical axis and correction optics are placed before the camera to enable the system to image the tilted plane that is illuminated by the illumination light sheet. As OPM only requires a single microscope objective near to the sample, it is compatible with conventional commercial microscope frames and sample mounting techniques, including arrays of samples in 96 and 384-well plates. Our recent publications on this work can be found here.

OPM wiki